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FX.co ★ Cytokinetics Starts Trial For CK-586 In HFpEF

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typeContent_19130:::2025-01-21T22:15:00

Cytokinetics Starts Trial For CK-586 In HFpEF

Cytokinetics, Inc. (CYTK), a biopharmaceutical firm specializing in muscle biology, announced on Monday the initiation of the AMBER-HFpEF trial. This Phase 2 clinical study is set to evaluate CK-586 in patients experiencing heart failure with preserved ejection fraction, known as HFpEF.

CK-586 is a cardiac myosin inhibitor being developed for HFpEF patients exhibiting hypercontractility and ventricular hypertrophy. The AMBER-HFpEF trial is a randomized, double-blind, placebo-controlled, multi-center study aimed at assessing the safety, tolerability, and efficacy of CK-586.

Building on encouraging data from prior studies in related conditions, such as non-obstructive hypertrophic cardiomyopathy (nHCM), this trial seeks to deliver further insights into CK-586's potential to enhance heart function and alleviate symptoms for HFpEF patients. Despite advancements in heart failure treatments, HFpEF remains a condition that severely affects quality of life and carries a poor prognosis.

Cytokinetics intends to enroll roughly 60 patients who will undergo three escalating doses to examine CK-586's impact on critical cardiovascular indicators.

This trial represents a significant advancement in the company's mission to develop targeted, effective treatments for heart failure patients with preserved ejection fraction.

Currently, CYTK's stock is trading at $45.70, reflecting a decrease of 0.09%.

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